920509-32-6 Resmetirom

Lastnosti

Videz rumen in oranžno kristalno trdno
Gostota 1,65 ± 0. 1 g/cm3
Shranjevalna temperatura. Inertno vzdušje, shranite v zamrzovalnik, pod -20
topnost DMSO: 59. 0 (max conc. mg/ml); 135.56 (max conc. mm)
PKA3.96 ± 0. 40
 

Vloga:

Resmetirom je selektivni agonist, ki cilja na ščitnični hormonski receptor beta (Thr -). To zdravilo lahko posebej prevzamejo jetrne celice in uravnava več presnovnih poti v jetrih z aktiviranjem THR - s tem doseže več učinkov, kot so zmanjšanje kopičenja jeter, spodbujanje presnove maščobnih kislin, zmanjšanje vneme jeter in uravnavanje presnove holesterola.

 

Sinonime:

Resmetirom

Mgl -3196

920509-32-6

Rezdiffra

Nj } yl) oxy] fenil] -3, 5- dioxo -1, 2, 4- triazine -6- karbonitrile

spojina 53 [PMID: 24712661]

1,2, 4- triazine -6- karbonitrile, 2- (3, 5- dichloro -4- ((1, 6- dihydro -5- (1- metyletyl) -6- ox o -3- pyridazinil) oxy) fenil) -2, 3,4, 5- tetrahydro -3, 5- dioxo-

2- (3, 5- dichloro -4- ((5- izopropil -6- oxo -1, 6-}}} yl) y) fenil) -3, 5- dioxo {{11}, 3,4, 5- tetrahidro- (1,2,4) triazin -6- karbonitril

Spojina 53 (PMID: 24712661)

1,2, 4- triazine -6- karbonitrile, 2- [3, 5- dichloro -4- [[1, 6- dihydro -5- (1- metyletyl) -6- ox o -3- pyridazinyl] oxy] fenil] -2, 3,4, 5- tetrahydro -3, 5- dioxo-

Resmetiromum

Rezdiffra

2- (3, 5- dichloro -4- ((6-} oxo -5- (propan {6}} yl) -3- dihydropyridazin ) fenil) -3, 5- dioxo -2, 3,4, 5- tetrahydro -1, 2, 4-}}}} carbonitrile

2- (3, 5- dichloro -4- ( } yl) oxy) fenil) -3, 5- dioxo -1, 2, 4- triazine -6- karbonitrile

2- (3, 5- dichloro -4- {[{4}}} oxo -5- (propan {6}} yl) {{9 {9}} dihropyridina } Phenyl) -3, 5- dioxo {{12}, 3,4, 5- tetrahydro -1, 2, 4-}}} carbonitrile

2- {3, 5- dichloro -4- [(5- Isopropyl -6- oxo -1 h-pyridazin -3- yl) o XY] Phenyl} -3, 5- dioxo -4 h -1, 2, 4- triazin -6- karbonitrile

2- (3, 5- dichloro -4- (5- Isopropyl -6- oxo -1, 6- dihidropiridazin {{8} yLoxy) pH enil) -3, 5- dioxo -2, 3,4, 5- tetrahydro -1, 2, 4-}}}} ogljikorile

2-(4-(1,6-dihydro-5-isopropyl-6-oxopyridazin-3-yloxy)-3,5-dichloroph enyl) -2, 3,4, 5- tetrahydro -3, 5- dioxo -1, 2, 4-}}}} ogljikorilj

2- [3, 5- dichloro -4- (5- Isopropyl -6- oxo -1, 6-}}} yLoxy ) -pHenil] -3, 5- dioxo -2, 3,4, 5- tetrahidro- [1,2,4] triazin -6- karbonitril

2-[3,5-Dichloro-4-[[1,6-dihydro-5-(1-methylethyl)-6-oxo-3-pyridazinyl]oxy ] Phenyl] -2, 3,4, 5- tetrahydro -3, 5- dioxo -1, 2, 4-}}} carbonitrile

 

Priljubljena oznake: 920509-32-6 Resmetirom, Kitajska 920509-32-6 Proizvajalci Resmetirom, dobavitelji